<p>Apatinib Plus Temozolomide for Recurrent Glioblastoma: An Uncontrolled, Open-Label Study</p>
نویسندگان
چکیده
منابع مشابه
Bevacizumab and daily temozolomide for recurrent glioblastoma.
BACKGROUND The authors performed a phase 2 trial of combined protracted daily temozolomide and biweekly bevacizumab for patients with recurrent glioblastoma who had previously received radiation therapy and temozolomide. METHODS There was no limit on the number of previous disease progressions or previous regimens allowed. Thirty-two adult patients were enrolled. Patients received temozolomid...
متن کاملAccelerated hyperfractionation plus temozolomide in glioblastoma
INTRODUCTION Hyperfractionated (HFRT) or accelerated hyperfractionated radiotherapy (AHFRT) have been discussed as a potential treatment for glioblastoma based on a hypothesized reduction of late radiation injury and prevention of repopulation. HFRT and AHFRT have been examined extensively in the pre-Temozolomide era with inconclusive results. In this study we examined the role of accelerated h...
متن کاملBevacizumab and Temozolomide Plus Radiation Regimen for Glioblastoma Multiforme.
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addr...
متن کاملBevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
BACKGROUND Standard therapy for newly diagnosed glioblastoma is radiotherapy plus temozolomide. In this phase 3 study, we evaluated the effect of the addition of bevacizumab to radiotherapy-temozolomide for the treatment of newly diagnosed glioblastoma. METHODS We randomly assigned patients with supratentorial glioblastoma to receive intravenous bevacizumab (10 mg per kilogram of body weight ...
متن کاملThe efficacy of temozolomide for recurrent glioblastoma multiforme.
BACKGROUND AND PURPOSE The efficacy of temozolomide (TMZ) in recurrent glioblastoma multiforme (GBM) has been evaluated by several clinical trials. A meta-analysis to assess the overall efficacy of TMZ in the treatment of recurrent GBM was carried out by the authors. METHODS Medline, EMBASE database and the Cochrane Library were searched for relevant studies. Eligible studies were clinical tr...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2019
ISSN: 1178-6930
DOI: 10.2147/ott.s226804